FMO3 on sale

Dr Dolphin was part of the team who first demonstrated that mutations in the FMO3 gene are the cause of the inherited (primary form) of TMAU.

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FMO3 on sale

Postby PoetFire » Fri Feb 08, 2013 11:30 am

Hello Colin

Someone posted this link in another category.

http://www.abcam.com/FMO3-antibody-ab62178.html

Do you think any type of FMO3 on sale to researchers may have some therapautic use now or someday ? (e.g. such as ingesting FMO3 protein)
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Re: FMO3 on sale

Postby Weak » Sat Feb 09, 2013 5:57 am

Yes, I believe someone did post about that. As I said before it could always be a scam, I try to watch out for people who are offering just what you need, if so then why isnt the TMAU community ablaze with news of something like this.

Someone should look into it though as you never know. It could be helpful.
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Re: FMO3 on sale

Postby Tenacity » Wed Feb 13, 2013 7:10 pm

Hi,

I replied to the other thread as well. This isn't FM03, it's an antibody that attacks the FM03 protein. It's designed for use in medical experiments on animals.

It would still be interesting to know if Dr Dolphin thinks this kind of animal research (ie the use of animal "models") can tell us anything about treating TMAU, or if he thinks FM03 supplements will ever become available to patients. :)
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Re: FMO3 on sale

Postby FADworker » Wed Feb 13, 2013 10:02 pm

Tenacity wrote:Hi,

I replied to the other thread as well. This isn't FM03, it's an antibody that attacks the FM03 protein. It's designed for use in medical experiments on animals.

It would still be interesting to know if Dr Dolphin thinks this kind of animal research (ie the use of animal "models") can tell us anything about treating TMAU, or if he thinks FM03 supplements will ever become available to patients. :)


Antibodies are produced by our immune system in response to infection by bacteria, viruses, etc and they bind specifically to proteins on those infectious agents to help destroy them. Antibodies can also be produced in the lab to be used as tools. This particular antibody has been made to specifically bind to human FMO3 and has many uses in the lab. To say 'It's designed for use in medical experiments on animals" is not really correct becuase an antibody is used to detect the 'antigen' it binds to - in this case FMO3 - in experiemnts that don't involve animals directly.

As for 'FMO3 supplements' then I'm afraid that's not really viable as FMO3 is a protein which, if ingested, would be digested in the stomach in the same way as any other protein we eat would be digested. I have a freezer full of human FMO3 protein and it can be bought from several companies. However, they're only designed to be used as reagents for lab experiments not, in any way, as a 'supplement' in TMAu.
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Re: FMO3 on sale

Postby PoetFire » Wed Feb 13, 2013 10:49 pm

Antibodies are produced by our immune system in response to infection by bacteria, viruses, etc and they bind specifically to proteins on those infectious agents to help destroy them. Antibodies can also be produced in the lab to be used as tools. This particular antibody has been made to specifically bind to human FMO3 and has many uses in the lab. To say 'It's designed for use in medical experiments on animals" is not really correct becuase an antibody is used to detect the 'antigen' it binds to - in this case FMO3 - in experiemnts that don't involve animals directly.

As for 'FMO3 supplements' then I'm afraid that's not really viable as FMO3 is a protein which, if ingested, would be digested in the stomach in the same way as any other protein we eat would be digested. I have a freezer full of human FMO3 protein and it can be bought from several companies. However, they're only designed to be used as reagents for lab experiments not, in any way, as a 'supplement' in TMAu.


Thanks for the reply.

I was wondering since TMA and presumably many other odourous sulfide/amine FMO3 substrates (?) are produced in the colon, that perhaps taking FMO3 protein orally may at least let some reach the colon to oxidize the substrates on site. I guess it's a long shot or not feasible ?
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Re: FMO3 on sale

Postby Tenacity » Wed Feb 13, 2013 11:28 pm

FADworker wrote:This particular antibody has been made to specifically bind to human FMO3 and has many uses in the lab. To say 'It's designed for use in medical experiments on animals" is not really correct becuase an antibody is used to detect the 'antigen' it binds to - in this case FMO3 - in experiemnts that don't involve animals directly.


Sorry, my mistake. I was just trying to explain that this wasn't FMO3, as some people seemed to think it was. I didn't really take the time to find out and understand the practical uses of the product, and hence probably shouldn't have posted a reply at all.

Thanks very much for answering the question. Very interesting answer!
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Re: FMO3 on sale

Postby Lauren23 » Sat Sep 13, 2014 7:03 am

After learning about the importance of telomeres--the "end tabs" of a DNA strand, and new supplements which might activate these telomeres in order to cure disease and prevent aging, I cannot help but wonder if this has any application to non-genetic mutations of the FMO 3 enzyme.

For instance, if one developed TMAU from taking a drug which altered the FMO 3 enzyme, might activating one's telomerase in turn help the enzyme to function properly again? :lol:
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Re: FMO3 on sale

Postby FADworker » Mon Sep 15, 2014 5:28 pm

Lauren23 wrote:For instance, if one developed TMAU from taking a drug which altered the FMO 3 enzyme, might activating one's telomerase in turn help the enzyme to function properly again? :lol:


Nope - no connection that I can see.
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