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Re: test results - help, please.

PostPosted: Fri Nov 14, 2014 8:46 pm
by PoetFire
Hi Pebbles

I am no expert of course, and you should consult an expert

My own amateur review of your result is :
TMA is oxidized by FMO3 into TMAO

Your total TMA load : This is the amount of TMA generated. This would be TMA + TMAO . Your total load was 47.8 which is pretty low from what I have seen of other test results. So you didn't generate much TMA

TMA level : I think Sheffield's 'normal' TMA level is around <10.9. You were 12 which is quite close. Maybe this is why you were told it was 'good'

TMA/TMAO ratio : Since FMO3 oxidizes TMA into TMAO, this is supposed to be a good indicator of FMO3 function. I think Sheffield reckon the ratio should be <0.21. You were 0.33 which seems a bit higher. In % terms, it's a case of working out how much % of TMA load was oxidized into TMAO. I think yours works out around 67%. Sheffield reckon normal should be >79% and Dr Liz Shephard (FMO3 expert) reckons it should be >90%.

So the result seems to suggest TMAU1 but I have my reservations about the test (partly because results can vary so much in one person) . I would certainly get the DNA test done.

Re: test results - help, please.

PostPosted: Sat Nov 15, 2014 8:02 am
by Pebble
Thank you for the explanation. They were not keen to let me have DNA test when I asked.
I am guessing that they are quite expensive to carry out.
Keep calm and carry on :)

Re: test results - help, please.

PostPosted: Sun Nov 16, 2014 10:10 am
by PoetFire
Hi Pebble

From the result I would say you are entitled to the DNA test as the result suggests possible TMAU1 (in this one result). I am guessing it probably recommended DNA testing on the result sheet.

Re: test results - help, please.

PostPosted: Sun Nov 16, 2014 11:22 am
by Pebble
Thanks Poetfire

Re: test results - help, please.

PostPosted: Mon Nov 17, 2014 10:58 am
by PoetFire
Hi Pebble

I think I saw your original result

I think it suggested not TMAU1.

I think this is pretty common, people getting TMAU1 then not TMAU1 including myself. There's a lot to be understood about the disorder due to lack of interest by researchers. I think the problem is that that the 'danger zone' is underestimated. If someone feels they have a transient smell problem and get a TMAU diagnosis at any point then my own suspicion would be that FMO3 substrates may be an issue.

The 'severe' TMAU type I think is rare, but not the transient 'close to the border' type which is probably the majority of us.

I think also FMO3 may be inhibited by things such as hormones, maybe even emotions etc (which are all chemicals). So it's not as clearcut as suggested in medical literature.

I think people should test more than once. Ideally I would test a lot but this is not practical of course. It should be really, like glucose testing for diabetes. But the health system doesn't currently care.

Re: test results - help, please.

PostPosted: Mon Nov 17, 2014 11:26 am
by Pebble
Hi Poetfire,

When I first got tested the TMA was about 21 I think & that's why they said this one was good as it was much less than before. I cant find those results though.
I also had a result back about a year ago when it was about 7. The tests I had done have fluctuated quite a bit and as you say it is hard to know as it could be down to hormones or whatever else.
Thanks once again for taking the time to look at my results though.