GENETIC TESTING

help with getting a diagnosis

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GENETIC TESTING

Postby Sophie1999 » Wed Jan 31, 2018 5:16 pm

Hi all,

I've had a few urine tests done and they've come back negative, however I'm still recieving comments about smells which I'm sure are originating from me. I want to get a genetic test done to see how my FMO3 gene is functioning - have any of you had this done? If so, are there any local places to London?

Many thanks,
Elise
Sophie1999
 
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Re: GENETIC TESTING

Postby PoetFire » Thu Feb 01, 2018 1:56 pm

Hi,

In a perfect society you could just order your FMO3 full sequencing direct and see if they coding part has any VARIANTS.
But our system is set up :
You can't test direct (easily).
You need to go thorugh a clinician, but their pattern is you can't DNA test if you were negative.

To DNA test you would need to jump through hoops even to get bits and pieces.

The FMO3 protein is a 532 amino acid sequence,
meaning it has 532 codon (a pair),
3 nucleotides make an amino acid so its 532 x 3 nucleotide sequence.

My advice would be :
Order an ancestry DNA test online (THAT LETS YOU SEARCH AND DOWNLOAD THE RAW DATA).
Usually they only do a few points of a gene (so not the full 532 code).
BUT
THEY OFTEN WILL REPORT COMMON VARIANTS of a gene.

In the case of FMO3 the most common variant are
E158K
E308G
V256M

might be written like this
rs2266782
rs2266780
rs1736557

Deciding if common variants will casuse symptoms is like art, the expert is subjective.
But I saw a lot of combos of carriers of these 3, which makes me suspicous.
Also very few experts have ever investigated FMO3.

random test, maybe go for myheritageDNA if its £69
https://dnatestingchoice.com/ancestry

I have tested 3 times cos I was getting bits and pieces rather than full sequence.
finally I got my full sequence so know my VARIANTS for sure.
Once you test full sequence you don't need to test again, but with heritage sites etc you will only get pieces of the 532 code sadly.
PoetFire
 
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Re: GENETIC TESTING

Postby Sophie1999 » Sun Feb 04, 2018 8:30 pm

Thanks so much for your reply poetfire! How did you go about getting a full sequencing? Was it because you tested positive therefore you could go through your GP? I will order the test and see if it comes back with bits and pieces.

Thanks again!
Soph
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Re: GENETIC TESTING

Postby Sophie1999 » Sun Feb 04, 2018 8:43 pm

Sophie1999
 
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Re: GENETIC TESTING

Postby PoetFire » Mon Feb 05, 2018 9:11 pm

that full genome one is a decent price.
I think I've seen slightly cheaper
https://www.dantelabs.com/collections/o ... sequencing

although they see full genome, i think often they dont test it all.
so make sure it has FMO3.
even then I cant be sure they test the whole 532 amino code for FMO3.

genome = all coding genes + junk
exome = all coding genes

but, you can faults in the junk which cripple the gene anyway.

but there is genos for exome
https://genos.co/sequencing.html

i dont like genome testers much as they like to have a 'front window' where the list terrible disorders you may carry.
I would rather just get the raw data and look myself.

thats why i also mention ancestry tests (no 'health' section)
and so cheap, and probably has the main fmo3 variants.

i did the full sequence through a lab in poland but they werent consumer friendly or set-up, i wouldnt recommend them.
NHS isnt great as they only let you know of variants they think may cause a problem.
They dont give all your fmo3 variants (if you have any other) ... i.e. Dr knows best.

if a genome test does the full genome it should have the full fmo3 code
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Re: GENETIC TESTING

Postby PoetFire » Mon Feb 05, 2018 9:13 pm

dante link is exome

this is their genome from their site
https://www.dantelabs.com/collections/o ... sequencing
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