TMAO conversion %

Dr Dolphin was part of the team who first demonstrated that mutations in the FMO3 gene are the cause of the inherited (primary form) of TMAU.

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TMAO conversion %

Postby PoetFire » Fri Jul 29, 2011 1:59 am

Dr Dolphin,

To diagnose people with genetic TMAU they check how much % TMA is converted to TMAO. I wondered what % level you would set this at to consider someone TMAU1 ? Sheffield currently seems to have it set at around 83%, which seems a little low ?
PoetFire
 
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Re: TMAO conversion %

Postby FADworker » Sat Jul 30, 2011 8:24 pm

PoetFire wrote:Dr Dolphin,

To diagnose people with genetic TMAU they check how much % TMA is converted to TMAO. I wondered what % level you would set this at to consider someone TMAU1 ? Sheffield currently seems to have it set at around 83%, which seems a little low ?


Hi,

I would defer to Sheffield's considerable experience in this area!
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Re: TMAO conversion %

Postby PoetFire » Sun Jul 31, 2011 8:07 am

Thanks.

I was thinking maybe around 80% was a bit conservative. 80% seemed a common threshold a decade or so ago (?), but nowadays it seems the lowest of the labs I know of. I have heard 85% suggested, with 85-95% being a grey area. Even +95% (grey - 90-95%), and in a new case study the writers were suggesting +97.3%. In the NIH TMAU article by Phillips/Shephard, they suggest 90%.

One great thing about Sheffield is that they are the only one of the main labs who seem to accept TMAU2 as an issue, and have set a TMA concentration level which people should not be over (10.8). I get the feeling the other labs only use the TMA/TMAO ratio and not the TMA concentration to diagnose (ie, only TMAU1).
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